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All Panama Tours & Cruises

Explore the colors and natural beauty of Panama - a land between the seas. Travel via dugout canoe to meet the indigenous Emberá people, visit gorgeous islands, snorkel the Caribbean and cruise through the world-famous Panama Canal. Choose from 568 cruises, small group tours and adventures to Panama travelling with the world's leading tour operators.
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6 Days
181 Days
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231 Trips (568 Trip Departures)
Featured17 Day Miami to LA via Panama Canal with Virgin Voyages
Cruise

17 Days (16 Nights) Miami to Los Angeles
Cruise Line: Virgin Voyages
Ship: Brilliant Lady
Departure: 21 March 2026
Countries Visited: USA, Colombia, Panama, Costa Rica (+2 more), Guatemala, Mexico
INSIDE
$5,161
OCEANVIEW
$5,665
BALCONY
$6,609
SUITE
-
From 5,161
View Trip
6 Day Independent Panama with Globus
New ReleaseTour

6 Days Panama City to Panama City
Operated By: Globus
Departures: Jul 2024 to Mar 2025
Trip Styles: Group, Short Break, Scenic
Countries Visited: Panama
Exclusive Savings
Save 50
From 2,312
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12 Day The Panama Canal & Costa Rica with Tauck
Cruise

12 Days (11 Nights) San Jose to Panama City
Operated By: Tauck
Departures: Jan 2025 to Jan 2025
Trip Styles: Group, Cruise
Countries Visited: Costa Rica, Panama
From 13,640
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12 Day The Panama Canal & Costa Rica - Westbound with Tauck
Cruise

12 Days (11 Nights) Panama City to San Jose
Operated By: Tauck
Departure: 18 January 2025
Trip Styles: Group, Cruise
Countries Visited: Panama, Costa Rica
From 14,250
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12 Day Costa Rica & Panama Discovery with Intrepid Travel
Tour

12 Days San Jose to Panama City
Operated By: Intrepid Travel
Departures: Jun 2024 to Dec 2025
Trip Styles: Adventure, Small Group
Countries Visited: Costa Rica, Panama
Limited Time Sale
Save 343
From 1,578
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14 Day Chile, Peru & Panama Voyage with Azamara Cruises
Cruise
 (1)

14 Days (13 Nights) San Antonio to Panama City
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 02 March 2026
Countries Visited: Chile, Peru, Panama
INSIDE
$5,330
OCEANVIEW
$6,365
BALCONY
$7,515
SUITE
$8,780
From 5,330
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8 Day Lima to Panama City with Silversea
Cruise

8 Days (7 Nights) Lima to Panama City
Cruise Line: Silversea
Ship: Silver Ray
Departure: 04 January 2025
Countries Visited: Peru, Ecuador, Panama
Port-to-PortExclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$4,158
From 4,158
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8 Day A Journey Traversing The Panama Canal with Explora Journeys
Cruise

8 Days (7 Nights) Panama City to Miami
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 24 May 2024
Countries Visited: Panama, Colombia, USA
Exclusive DealUnique Escapes
INSIDE
-
OCEANVIEW
-
BALCONY
$5,341
SUITE
$6,519
From 5,341
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14 Day Cycle Nicaragua to the Panama Canal with Explore!
Tour

14 Days Granada to Panama City
Operated By: Explore!
Departures: Oct 2024 to Nov 2025
Trip Styles: Adventure, Small Group, Cycling
Countries Visited: Costa Rica, Panama, Nicaragua
Exclusive Savings
Save 147
From 6,997
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8 Day Panama City to Fort Lauderdale with Silversea
Cruise

8 Days (7 Nights) Panama City to Fort Lauderdale
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 20 May 2025
Countries Visited: Panama, Colombia, USA
Port-to-PortExclusive Solo Offer
INSIDE
-
OCEANVIEW
$4,158
BALCONY
$5,049
SUITE
-
From 4,158
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14 Day Highlights Of South America – Land And Sea Expedition with Hurtigruten
Tour + Cruise

14 Days Colon to Lima
Operated By: Hurtigruten
Ship: MS Fram
Departure: 06 October 2024
Countries Visited: Panama, Ecuador, Peru
Exclusive Deal
INSIDE
-
OCEANVIEW
$20,598
BALCONY
-
SUITE
$22,835
Save 2,802
From 20,598
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10 Day Panama City to Fort Lauderdale with Silversea
Cruise

10 Days (9 Nights) Panama City to Fort Lauderdale
Cruise Line: Silversea
Ship: Silver Ray
Departure: 11 January 2025
Countries Visited: Aruba, Colombia, Panama, USA
Port-to-PortExclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$6,187
From 6,187
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12 Day Los Angeles to Panama City with Silversea
Cruise

12 Days (11 Nights) Los Angeles to Panama City
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 09 May 2025
Countries Visited: USA, Mexico, Costa Rica, Panama
Port-to-PortExclusive Solo Offer
INSIDE
-
OCEANVIEW
$6,138
BALCONY
$7,326
SUITE
-
From 6,138
View Trip
15 Day Treasures Of The Pacific Coast - Panama To Chile with Hurtigruten
Cruise

15 Days (14 Nights) Colon to Valparaiso
Cruise Line: Hurtigruten
Ships: MS Fram, MS Roald Amundsen
Departures: Oct 2024 to Oct 2024
Countries Visited: Panama, Ecuador, Peru, Chile
Exclusive Deal
INSIDE
-
OCEANVIEW
$6,549
BALCONY
-
SUITE
$9,145
Save 4,779
From 6,549
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19 Day Andes & South America with Princess
Cruise
 (3)

19 Days (18 Nights) Los Angeles to Santiago
Cruise Line: Princess
Ship: Majestic Princess
Departure: 01 December 2024
Countries Visited: USA, Mexico, Panama, Peru (+1 more), Chile
INSIDE
$2,334
OCEANVIEW
-
BALCONY
$3,057
SUITE
$3,888
From 2,334
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (1)

17 Days (16 Nights) Fort Lauderdale to Los Angeles
Cruise Line: Princess
Ship: Coral Princess
Departures: Jan 2026 to Apr 2026
Countries Visited: USA, Colombia, Panama, Costa Rica (+1 more), Mexico
INSIDE
$3,359
OCEANVIEW
$3,666
BALCONY
$4,824
SUITE
$5,705
From 3,359
View Trip
10 Day Panama Canal - Miami with Norwegian Cruise Line
Cruise

10 Days (9 Nights) Miami to Panama City
Ship: Norwegian Gem
Departure: 02 December 2024
Countries Visited: USA, Dominican Republic, Curacao, Aruba (+1 more), Panama
Exclusive Solo Offer
INSIDE
$2,072
OCEANVIEW
$2,300
BALCONY
$3,478
SUITE
$3,632
From 2,072
View Trip
18 Day Panama Canal & the Pacific Coast with Viking Cruises
Cruise

18 Days (17 Nights) Los Angeles to Fort Lauderdale
Cruise Line: Viking Cruises
Ship: Viking Neptune
Departure: 05 April 2025
Countries Visited: USA, Mexico, Costa Rica, Panama (+1 more), Colombia
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$10,885
SUITE
$20,785
Save 1,110
From 10,885
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13 Day Panama Canal - Miami with Norwegian Cruise Line
Cruise

13 Days (12 Nights) Miami to Lima
Ship: Norwegian Jade
Departure: 27 February 2026
Countries Visited: USA, Colombia, Panama, Ecuador (+1 more), Peru
INSIDE
$3,763
OCEANVIEW
$3,947
BALCONY
$6,013
SUITE
$6,212
From 3,763
View Trip
16 Day Panama Canal - Miami with Norwegian Cruise Line
Cruise

16 Days (15 Nights) Miami to Los Angeles
Ship: Norwegian Joy
Departure: 30 November 2024
Countries Visited: USA, Colombia, Panama, Guatemala (+1 more), Mexico
INSIDE
$2,950
OCEANVIEW
$3,347
BALCONY
$4,066
SUITE
$4,372
From 2,950
View Trip
10 Day Western Caribbean Cruise with Royal Caribbean
Cruise

10 Days (9 Nights) Tampa to Tampa
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Oct 2024 to Feb 2025
Countries Visited: USA, Cayman Islands, Panama, Costa Rica (+1 more), Mexico
Exclusive Deal
INSIDE
$1,379
OCEANVIEW
$1,399
BALCONY
$1,855
SUITE
$3,128
Save 1,329
From 1,379
View Trip
11 Day Tropical Tastes Of The Riviera with Regent Seven Seas
Cruise

11 Days (10 Nights) Panama City to Los Angeles
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 15 January 2026
Countries Visited: Panama, Costa Rica, Nicaragua, Mexico (+1 more), USA
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$9,618
SUITE
$10,143
Save 6,132
From 9,618
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18 Day Pacific Latin America — Ancient Wonders And National Parks with Hurtigruten
Cruise

18 Days (17 Nights) Valparaiso to Puntarenas
Cruise Line: Hurtigruten
Ship: MS Roald Amundsen
Departure: 04 April 2025
Countries Visited: Chile, Peru, Ecuador, Panama (+1 more), Costa Rica
Exclusive Deal
INSIDE
-
OCEANVIEW
$13,547
BALCONY
$16,121
SUITE
$19,238
Save 6,877
From 13,547
View Trip
18 Day Panama Canal & the Pacific Coast with Viking Cruises
Cruise

18 Days (17 Nights) Fort Lauderdale to Los Angeles
Cruise Line: Viking Cruises
Ships: Viking Neptune, Viking Sky
Departures: Oct 2024 to Dec 2025
Countries Visited: USA, Mexico, Colombia, Panama (+1 more), Costa Rica
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$9,895
SUITE
$19,795
Save 1,110
From 9,895
View Trip
10 Day Panama Canal - Miami with Norwegian Cruise Line
Cruise

10 Days (9 Nights) Miami to Panama City
Ship: Norwegian Jade
Departure: 01 November 2025
Countries Visited: USA, Dominican Republic, Aruba, Colombia (+1 more), Panama
INSIDE
$2,370
OCEANVIEW
$2,829
BALCONY
$3,977
SUITE
$4,282
From 2,370
View Trip
18 Day New York To San Francisco with Cunard
Cruise

18 Days (17 Nights) New York to San Francisco
Cruise Line: Cunard
Ship: Queen Anne
Departure: 18 January 2025
Countries Visited: USA, Aruba, Panama, Guatemala (+1 more), Mexico
INSIDE
$4,945
OCEANVIEW
$7,242
BALCONY
$7,846
SUITE
-
From 4,945
View Trip
13 Day Tropical Waters And Remote Island Communities In The Caribbean with Hurtigruten
Cruise

13 Days (12 Nights) Miami to Colon
Cruise Line: Hurtigruten
Ship: MS Roald Amundsen
Departure: 25 September 2024
Countries Visited: USA, Belize, Honduras, Nicaragua (+1 more), Panama
Exclusive Deal
INSIDE
-
OCEANVIEW
$11,640
BALCONY
$13,561
SUITE
$15,646
Save 3,520
From 11,640
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20 Day Panama Canal & the Americas with Viking Cruises
Cruise

20 Days (19 Nights) Santiago to New York
Cruise Line: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Mar 2026 to Mar 2026
Countries Visited: Chile, Peru, Panama, Jamaica (+1 more), Bahamas
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$17,815
SUITE
$25,735
Save 1,180
From 17,815
View Trip
19 Day Los Angeles to Fort Lauderdale with Silversea
Cruise

19 Days (18 Nights) Los Angeles to Fort Lauderdale
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 09 May 2025
Countries Visited: USA, Mexico, Costa Rica, Panama (+1 more), Colombia
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$14,058
BALCONY
$15,345
SUITE
$24,948
From 14,058
View Trip
19 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (2)

19 Days (18 Nights) Los Angeles to New York
Cruise Line: Princess
Ship: Island Princess
Departures: May 2025 to May 2026
Countries Visited: USA, Mexico, Nicaragua, Costa Rica (+2 more), Panama, Aruba
INSIDE
$3,093
OCEANVIEW
$3,213
BALCONY
$4,330
SUITE
$5,403
From 3,093
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (1)

17 Days (16 Nights) Los Angeles to Fort Lauderdale
Cruise Line: Princess
Ships: Coral Princess, Island Princess
Departures: Feb 2025 to Feb 2026
Countries Visited: USA, Mexico, Nicaragua, Costa Rica (+2 more), Panama, Aruba
INSIDE
$2,603
OCEANVIEW
$2,848
BALCONY
$3,699
SUITE
$4,708
From 2,603
View Trip
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