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Cruises from Spain to Italy

Are you looking for a cruise from Spain to Italy? April and September are the most popular months to cruise between Spain and Italy and there are 215 departures available from sixteen of the world's leading cruise lines.
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113 Cruises (215 Cruise Departures)
11 Day Mediterranean Overture with Seabourn
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Seabourn
Ship: Ovation
Departures: May 2025 to Oct 2025
Countries Visited: Spain, France, Monaco, Italy (+2 more), Corsica, Sardinia
The Sail Away Event
INSIDE
-
OCEANVIEW
-
BALCONY
$8,424
SUITE
$15,913
From 8,424
View Trip
11 Day Europe - Western Mediterranean with Norwegian Cruise Line
Cruise

11 Days (10 Nights) Barcelona to Venice
Ship: Norwegian Escape
Departure: 11 August 2024
Countries Visited: Spain, France, Italy, Sicily (+3 more), Malta, Greece, Croatia
INSIDE
$2,798
OCEANVIEW
$3,638
BALCONY
$3,716
SUITE
$4,175
From 2,798
View Trip
25 Day Mediterranean Autumn with Oceania Cruises
Cruise

25 Days (24 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 02 October 2024
Countries Visited: Spain, France, Corsica, Italy (+5 more), Sicily, Greece, Montenegro, Croatia, Malta
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$15,559
SUITE
$22,499
Save 2,131
From 15,559
View Trip
8 Day A Journey From Barcelona To Rome with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 13 May 2025
Countries Visited: Spain, France, Corsica, Sardinia (+1 more), Italy
Unique Escapes
INSIDE
-
OCEANVIEW
-
BALCONY
$6,192
SUITE
$7,529
From 6,192
View Trip
8 Day Western Mediterranean with Cunard
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 08 September 2025
Countries Visited: Spain, Sardinia, Corsica, Sicily (+1 more), Italy
INSIDE
$1,427
OCEANVIEW
$1,645
BALCONY
$1,873
SUITE
$3,833
From 1,427
View Trip
4 Day Mediterranean with MSC Cruises
Cruise

4 Days (3 Nights) Alicante to Genoa
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departure: 07 November 2024
Countries Visited: Spain, Sardinia, Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$698
SUITE
-
From 698
View Trip
11 Day Greek Isles & Turkey Cruise with Celebrity Cruises
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departures: May 2025 to Oct 2025
Countries Visited: Spain, Greece, Turkey, Italy
Exclusive DealExclusive Offer
INSIDE
$2,494
OCEANVIEW
$3,055
BALCONY
$3,169
SUITE
$8,475
Save 3,803
From 2,494
View Trip
8 Day Florence, Rome, Palma & More with Virgin Voyages
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Virgin Voyages
Ship: Scarlet Lady
Departure: 29 June 2025
Countries Visited: Spain, France, Corsica, Italy
Up to 80% Off Second Sailor + Free Upgrade
INSIDE
$2,288
OCEANVIEW
$2,679
BALCONY
$2,951
SUITE
$6,552
From 2,288
View Trip
10 Day Italian Riviera & France Cruise with Celebrity Cruises
Cruise

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departures: Sep 2024 to Oct 2024
Countries Visited: Spain, France, Corsica, Italy (+2 more), Malta, Sicily
Exclusive DealExclusive Offer
INSIDE
$2,660
OCEANVIEW
$3,716
BALCONY
$4,373
SUITE
$10,053
Save 3,590
From 2,660
View Trip
8 Day Spain, France & Italy Cruise with Celebrity Cruises
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 17 August 2024
Countries Visited: Spain, France, Italy
Exclusive DealExclusive Offer
INSIDE
$1,814
OCEANVIEW
$2,056
BALCONY
$2,271
SUITE
$5,586
Save 2,423
From 1,772
View Trip
23 Day Mediterranean Magic & Tyrrhenian Treasures with Seabourn
Cruise

23 Days (22 Nights) Barcelona to Rome
Cruise Line: Seabourn
Ship: Ovation
Departure: 31 August 2024
Countries Visited: Spain, Sardinia, France, Italy (+4 more), Monaco, Sicily, Malta, Corsica
More Moments On Us Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$22,890
SUITE
-
From 22,890
View Trip
8 Day Italy, France And Spain with Cunard
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departures: May 2026 to Jun 2026
Countries Visited: Spain, Corsica, Sicily, Italy
INSIDE
$1,387
OCEANVIEW
$1,585
BALCONY
$1,783
SUITE
$3,763
From 1,387
View Trip
15 Day Italy, France And Spain with Cunard
Cruise

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 07 July 2025
Countries Visited: Spain, Corsica, France, Italy (+2 more), Sardinia, Sicily
INSIDE
$2,855
OCEANVIEW
$3,033
BALCONY
$3,568
SUITE
$7,399
From 2,855
View Trip
11 Day Western Mediterranean Cruise with Royal Caribbean
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Royal Caribbean
Ship: Voyager of the Seas
Departure: 16 May 2025
Countries Visited: Spain, Corsica, Sardinia, Sicily (+2 more), Greece, Italy
Exclusive Deal
INSIDE
$3,054
OCEANVIEW
$4,147
BALCONY
$5,621
SUITE
$11,886
Save 1,254
From 2,764
View Trip
4 Day Mediterranean with MSC Cruises
Cruise

4 Days (3 Nights) Malaga to Genoa
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 10 November 2024
Countries Visited: Spain, France, Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$669
SUITE
-
From 669
View Trip
8 Day A Journey From Barcelona To Civitavecchia with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 16 June 2025
Countries Visited: Spain, France, Corsica, Italy (+1 more), Sardinia
Unique EscapesPenthouse Dream Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$5,846
SUITE
$7,108
From 5,846
View Trip
5 Day MSC Grand Voyages with MSC Cruises
Cruise

5 Days (4 Nights) Valencia to Genoa
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 27 November 2024
Countries Visited: Spain, Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
$600
BALCONY
$728
SUITE
$1,421
From 600
View Trip
31 Day Jewels Of Spain, Italy & France with Seabourn
Cruise

31 Days (30 Nights) Barcelona to Rome
Cruise Line: Seabourn
Ship: Ovation
Departure: 11 July 2025
Countries Visited: Spain, Sardinia, France, Italy (+4 more), Monaco, Sicily, Malta, Corsica
The Sail Away Event
INSIDE
-
OCEANVIEW
-
BALCONY
$24,263
SUITE
$43,029
From 24,263
View Trip
13 Day Vita Est Bona with Regent Seven Seas
Cruise

13 Days (12 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Mariner
Departure: 24 August 2024
Countries Visited: Spain, France, Monaco, Italy (+1 more), Sardinia
Explore More OfferExclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$10,579
SUITE
$11,723
Save 11,141
From 10,579
View Trip
4 Day MSC Grand Voyages with MSC Cruises
Cruise

4 Days (3 Nights) Barcelona to Genoa
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 28 November 2024
Countries Visited: Spain, Italy
Exclusive Deal
INSIDE
$470
OCEANVIEW
$569
BALCONY
$678
SUITE
$1,093
From 470
View Trip
10 Day Canary Islands And Madeira with MSC Cruises
Cruise

10 Days (9 Nights) Santa Cruz de Tenerife to Bari
Cruise Line: MSC Cruises
Ship: MSC Opera
Departure: 23 March 2025
Countries Visited: Spain, Morocco, Sicily, Greece (+1 more), Italy
Save And Sail Offer
INSIDE
$1,748
OCEANVIEW
$2,194
BALCONY
$3,382
SUITE
$5,213
From 1,748
View Trip
12 Day Barcelona to Civitavecchia with Virgin Voyages
Cruise

12 Days (11 Nights) Barcelona to Rome
Cruise Line: Virgin Voyages
Ship: Scarlet Lady
Departure: 03 November 2024
Countries Visited: Spain, France, Italy, Corsica (+1 more), Sardinia
INSIDE
$3,276
OCEANVIEW
$3,694
BALCONY
$4,204
SUITE
-
From 3,276
View Trip
15 Day Adriatic And Western Mediterranean with Cunard
Cruise

15 Days (14 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Victoria
Departures: May 2026 to Jun 2026
Countries Visited: Spain, Corsica, Sicily, Italy (+3 more), Greece, Montenegro, Croatia
INSIDE
$2,974
OCEANVIEW
$3,320
BALCONY
$3,766
SUITE
$7,924
From 2,974
View Trip
12 Day Europe - Western Mediterranean - Barcelona with Norwegian Cruise Line
Cruise

12 Days (11 Nights) Barcelona to Venice
Ships: Norwegian Breakaway, Norwegian Escape
Departures: Sep 2024 to Sep 2025
Countries Visited: Spain, France, Italy, Sicily (+3 more), Malta, Greece, Croatia
Exclusive Solo Offer
INSIDE
$3,685
OCEANVIEW
$4,297
BALCONY
$5,367
SUITE
$5,673
From 3,685
View Trip
8 Day Western Mediterranean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Royal Caribbean
Ship: Voyager of the Seas
Departure: 05 August 2024
Countries Visited: Spain, France, Corsica, Italy
Exclusive Deal
INSIDE
$2,317
OCEANVIEW
$2,345
BALCONY
$2,664
SUITE
$3,961
Save 815
From 1,740
View Trip
8 Day A Journey From Barcelona To Civitavecchia with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 06 October 2025
Countries Visited: Spain, France, Sardinia, Corsica (+1 more), Italy
Unique Escapes
INSIDE
-
OCEANVIEW
-
BALCONY
$5,504
SUITE
$6,692
From 5,504
View Trip
15 Day Italy And Adriatic with Cunard
Cruise

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 18 August 2025
Countries Visited: Spain, Malta, Italy, Croatia (+2 more), Montenegro, Greece
INSIDE
$2,766
OCEANVIEW
$3,212
BALCONY
$3,657
SUITE
$7,667
From 2,766
View Trip
8 Day Western Mediterranean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Royal Caribbean
Ship: Voyager of the Seas
Departures: Jun 2025 to Sep 2025
Countries Visited: Spain, France, Corsica, Italy
Exclusive Deal
INSIDE
$1,418
OCEANVIEW
$1,979
BALCONY
$2,489
SUITE
$3,491
Save 638
From 1,265
View Trip
8 Day Western Mediterranean with Royal Caribbean
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Royal Caribbean
Ship: Voyager of the Seas
Departure: 30 September 2024
Countries Visited: Spain, France, Corsica, Italy
Exclusive Deal
INSIDE
$2,002
OCEANVIEW
$2,665
BALCONY
$3,073
SUITE
$4,410
Save 774
From 1,650
View Trip
10 Day Greece, Malta & Turkey Cruise with Celebrity Cruises
Cruise

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 30 August 2025
Countries Visited: Spain, Malta, Greece, Turkey (+1 more), Italy
Exclusive DealExclusive Offer
INSIDE
$2,396
OCEANVIEW
$2,722
BALCONY
$3,016
SUITE
$9,396
Save 3,399
From 2,396
View Trip
Results: 31-60 of 113

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