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Cruises from Italy to Spain

Are you looking for a cruise from Italy to Spain? September is the most popular month to cruise between Italy and Spain and there are 231 departures available from sixteen of the world's leading cruise lines.
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127 Cruises (231 Cruise Departures)
13 Day Mediterranean Odyssey with Viking Cruises
Cruise

13 Days (12 Nights) Venice to Barcelona
Cruise Line: Viking Cruises
Ships: Viking Saturn, Viking Sea (+3 more), Viking Sky, Viking Star, Viking Vesta
Departures: May 2024 to Aug 2026
Countries Visited: Italy, Croatia, Greece, Monaco (+2 more), France, Spain
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$6,925
SUITE
$10,390
Save 1,250
From 6,925
View Trip
11 Day Grand Mediterranean with Princess
Cruise
 (3)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Majestic Princess
Departure: 30 June 2025
Countries Visited: Italy, Greece, Turkey, Sicily (+1 more), Spain
INSIDE
$2,934
OCEANVIEW
-
BALCONY
$4,237
SUITE
$5,151
From 2,934
View Trip
8 Day Iconic Western Mediterranean with Viking Cruises
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+8 more), Viking Neptune, Viking Saturn, Viking Sea, Viking Sky, Viking Star, Viking Vela, Viking Venus, Viking Vesta
Departures: Jul 2024 to Sep 2026
Countries Visited: Italy, Monaco, France, Spain
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$4,450
SUITE
$6,925
Save 1,279
From 4,450
View Trip
19 Day Malta & Mediterranean Romance with Holland America
Cruise
 (1)

19 Days (18 Nights) Rome to Barcelona
Cruise Line: Holland America
Ship: Oosterdam
Departure: 01 September 2024
Countries Visited: Italy, Sicily, Malta, Greece (+5 more), Turkey, Albania, Corsica, France, Spain
Have It All Offer
INSIDE
$5,178
OCEANVIEW
$5,822
BALCONY
$6,802
SUITE
$9,594
From 5,178
View Trip
12 Day Around Italy's Boot: Cote D'azur with Holland America
Cruise
 (1)

12 Days (11 Nights) Venice to Barcelona
Cruise Line: Holland America
Ship: Oosterdam
Departure: 30 August 2025
Countries Visited: Italy, Montenegro, Greece, Sicily (+2 more), France, Spain
Have It All Offer
INSIDE
$3,793
OCEANVIEW
$3,991
BALCONY
$4,981
SUITE
$6,862
From 3,793
View Trip
10 Day Islands Of The Med Voyage with Azamara Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 18 October 2024
Countries Visited: Italy, Corsica, Sardinia, Spain
INSIDE
-
OCEANVIEW
$2,869
BALCONY
$4,571
SUITE
$6,490
From 2,869
View Trip
11 Day Mediterranean Melange with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 29 October 2025
Countries Visited: Italy, Sicily, Sardinia, Corsica (+3 more), Monaco, France, Spain
Exclusive Deal
INSIDE
$4,419
OCEANVIEW
$4,874
BALCONY
$7,320
SUITE
$9,854
Save 2,031
From 4,419
View Trip
11 Day Renaissance Triumphs with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Riviera
Departure: 04 November 2024
Countries Visited: Italy, Sicily, Malta, France (+1 more), Spain
Exclusive DealSingles Special Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$6,398
SUITE
$9,091
Save 2,052
From 6,398
View Trip
12 Day Rivieras & Yacht Havens Voyage with Azamara Cruises
Cruise
 (1)

12 Days (11 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 26 August 2025
Countries Visited: Italy, Monaco, France, Spain
INSIDE
$4,368
OCEANVIEW
$4,829
BALCONY
$5,519
SUITE
$7,588
From 4,368
View Trip
11 Day Adriatic & Med Gateways Voyage with Azamara Cruises
Cruise
 (1)

11 Days (10 Nights) Venice to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 01 June 2026
Countries Visited: Italy, Slovenia, Croatia, Montenegro (+2 more), Monaco, Spain
INSIDE
$5,325
OCEANVIEW
$5,899
BALCONY
$6,819
SUITE
$9,348
From 5,325
View Trip
11 Day Autumnal Mediterranean with Oceania Cruises
Cruise
 (2)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 18 October 2025
Countries Visited: Italy, Sicily, Malta, Tunisia (+3 more), Monaco, France, Spain
Exclusive Deal
INSIDE
$4,726
OCEANVIEW
$5,181
BALCONY
$7,626
SUITE
$10,309
Save 2,034
From 4,726
View Trip
11 Day Adriatic & Med Gateways Voyage with Azamara Cruises
Cruise
 (1)

11 Days (10 Nights) Venice to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 30 May 2024
Countries Visited: Italy, Slovenia, Croatia, Montenegro (+2 more), Monaco, Spain
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$9,645
From 9,645
View Trip
10 Day Cities Of The Western Med Voyage with Azamara Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 31 October 2024
Countries Visited: Italy, Monaco, France, Spain
INSIDE
$2,033
OCEANVIEW
-
BALCONY
$4,228
SUITE
$5,512
From 2,033
View Trip
15 Day Adriatic And Western Mediterranean with Cunard
Cruise

15 Days (14 Nights) Trieste to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 02 June 2025
Countries Visited: Italy, Croatia, Malta, Corsica (+1 more), Spain
INSIDE
$2,825
OCEANVIEW
$3,202
BALCONY
$3,578
SUITE
$7,805
From 2,825
View Trip
15 Day Greece, Adriatic And Western Mediterranean with Cunard
Cruise

15 Days (14 Nights) Trieste to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 25 August 2025
Countries Visited: Italy, Croatia, Montenegro, Greece (+2 more), France, Spain
INSIDE
$2,766
OCEANVIEW
$3,212
BALCONY
$3,568
SUITE
$7,667
From 2,766
View Trip
22 Day Adriatic And Western Mediterranean with Cunard
Cruise

22 Days (21 Nights) Trieste to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 28 July 2025
Countries Visited: Italy, Croatia, Malta, France (+4 more), Sardinia, Sicily, Corsica, Spain
INSIDE
$3,927
OCEANVIEW
$4,283
BALCONY
$4,996
SUITE
$10,698
From 3,927
View Trip
8 Day Mediterranean Tapestry with Regent Seven Seas
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Navigator
Departure: 15 November 2024
Countries Visited: Italy, France, Spain
Mutiple Deals Available
INSIDE
-
OCEANVIEW
$3,830
BALCONY
$3,993
SUITE
$4,953
Save 7,440
From 3,830
View Trip
31 Day Riviera, Mediterranean & Tyrrhenian Treasures with Seabourn
Cruise

31 Days (30 Nights) Rome to Barcelona
Cruise Line: Seabourn
Ship: Ovation
Departure: 10 August 2025
Countries Visited: Italy, Malta, Tunisia, France (+5 more), Spain, Sardinia, Monaco, Sicily, Corsica
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$26,361
SUITE
$50,418
From 26,361
View Trip
10 Day Italy, France & Spain Cruise with Celebrity Cruises
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 24 August 2024
Countries Visited: Italy, Sicily, Malta, Corsica (+2 more), France, Spain
Exclusive DealExclusive Offer
INSIDE
$2,203
OCEANVIEW
$2,511
BALCONY
$3,336
SUITE
$7,843
Save 2,910
From 2,185
View Trip
8 Day Italy, France And Spain with Cunard
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departures: Jun 2024 to Sep 2024
Countries Visited: Italy, France, Spain
INSIDE
$1,882
OCEANVIEW
$2,179
BALCONY
$2,377
SUITE
$4,753
From 1,882
View Trip
13 Day Rome to Barcelona with Silversea
Cruise

13 Days (12 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Spirit
Departure: 16 May 2024
Countries Visited: Italy, Monaco, Spain, Malta
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$17,523
BALCONY
$20,889
SUITE
-
From 17,523
View Trip
3 Day Mediterranean with MSC Cruises
Cruise

3 Days (2 Nights) Livorno to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 23 June 2024
Countries Visited: Italy, France, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$522
SUITE
-
From 522
View Trip
11 Day Rome to Barcelona with Silversea
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Moon
Departure: 06 August 2024
Countries Visited: France, Italy, Spain
Mutiple Deals Available
INSIDE
-
OCEANVIEW
$8,860
BALCONY
$10,345
SUITE
$27,621
From 8,860
View Trip
15 Day Mediterranean with Greek Isles, Italy & Turkey with Princess
Cruise

15 Days (14 Nights) Naples to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departure: 27 September 2025
Countries Visited: Italy, Sicily, Greece, Turkey (+2 more), Montenegro, Spain
INSIDE
$3,958
OCEANVIEW
$4,925
BALCONY
$6,212
SUITE
$7,321
From 3,958
View Trip
11 Day Riviera & Mediterranean Jewels with Seabourn
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Seabourn
Ship: Ovation
Departures: Jul 2024 to Nov 2025
Countries Visited: Italy, Malta, Tunisia, France (+1 more), Spain
Earlybird SavingExclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$9,909
SUITE
$16,145
From 9,909
View Trip
10 Day Ultimate Italy, France & Spain Cruise with Royal Caribbean
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 01 July 2024
Countries Visited: Italy, Corsica, France, Spain
Exclusive Deal
INSIDE
$5,282
OCEANVIEW
$4,082
BALCONY
$6,645
SUITE
-
Save 1,600
From 3,727
View Trip
15 Day Italy, Spain And Adriatic with Cunard
Cruise

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 24 August 2026
Countries Visited: Italy, Greece, Montenegro, Croatia (+2 more), Malta, Spain
INSIDE
$3,320
OCEANVIEW
$3,667
BALCONY
$4,162
SUITE
$8,914
From 3,320
View Trip
8 Day A Journey From Civitavecchia To Barcelona with Explora Journeys
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departures: Aug 2025 to Sep 2025
Countries Visited: Italy, Sicily, Sardinia, Spain
Exclusive DealThe Total Luxury Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$5,846
SUITE
$7,108
From 8,747
View Trip
15 Day Charming Coasts & Treasures with Regent Seven Seas
Cruise

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 25 October 2025
Countries Visited: Italy, Sicily, Malta, Tunisia (+3 more), Corsica, Monaco, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$17,161
SUITE
$19,002
Save 6,959
From 17,161
View Trip
15 Day Mediterranean with Greek Isles, Italy & Turkey with Princess
Cruise

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departure: 06 September 2025
Countries Visited: Italy, Greece, Turkey, Montenegro (+2 more), Sicily, Spain
INSIDE
$3,730
OCEANVIEW
$4,595
BALCONY
$5,901
SUITE
$7,357
From 3,730
View Trip
Results: 1-30 of 127

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