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Panama Tours & Cruises Starting In September 2025

If you're looking at joining a tour to Panama in September 2025, we have 15 unique cruises, small group tours and adventures with 202 departures from the world's leading tour operators departing in September.
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Departures (September 2025)
< August 2025 October 2025 >
Duration
12 Days
87 Days
Types
Budget
Start & End Cities
Operators
Price
$1,300pp
$161,495pp
Countries
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15 Trips (202 Trip Departures)
12 Day Costa Rica & Panama Discovery with Intrepid Travel
Tour

12 Days San Jose to Panama City
Operated By: Intrepid Travel
Departures: May 2024 to Dec 2025
Trip Styles: Adventure, Small Group
Countries Visited: Costa Rica, Panama
Limited Time Sale
Save 302
From 1,608
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19 Day San Francisco To Miami with Cunard
Cruise
 (8)

19 Days (18 Nights) San Francisco to Miami
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 28 September 2025
Countries Visited: USA, Mexico, Costa Rica, Panama (+2 more), Colombia, Aruba
INSIDE
$3,668
OCEANVIEW
$4,163
BALCONY
$5,005
SUITE
$10,895
From 3,668
View Trip
22 Day Seattle To Miami with Cunard
Cruise
 (8)

22 Days (21 Nights) Seattle to Miami
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 25 September 2025
Countries Visited: USA, Mexico, Costa Rica, Panama (+2 more), Colombia, Aruba
INSIDE
$4,659
OCEANVIEW
$5,253
BALCONY
$6,144
SUITE
$13,668
From 4,659
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise

17 Days (16 Nights) Los Angeles to Fort Lauderdale
Cruise Line: Princess
Ship: Caribbean Princess
Departure: 30 September 2025
Countries Visited: USA, Mexico, Nicaragua, Costa Rica (+2 more), Panama, Aruba
INSIDE
$2,752
OCEANVIEW
$3,014
BALCONY
$4,138
SUITE
$5,980
From 2,752
View Trip
28 Day Amazing Central America with Intrepid Travel
Tour

28 Days Antigua to Panama City
Operated By: Intrepid Travel
Departures: May 2024 to Dec 2025
Trip Styles: Adventure, Small Group
Countries Visited: Guatemala, Honduras, El Salvador, Nicaragua (+2 more), Costa Rica, Panama
Exclusive Savings
Save 96
From 4,052
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19 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (2)

19 Days (18 Nights) New York to Los Angeles
Cruise Line: Princess
Ship: Island Princess
Departure: 18 September 2025
Countries Visited: USA, Turks and Caicos Islands, Aruba, Panama (+3 more), Costa Rica, Nicaragua, Mexico
INSIDE
$3,294
OCEANVIEW
$3,416
BALCONY
$4,908
SUITE
$5,516
From 3,294
View Trip
29 Day Seattle To Miami with Cunard
Cruise
 (8)

29 Days (28 Nights) Seattle to Miami
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 18 September 2025
Countries Visited: USA, Canada, Mexico, Costa Rica (+3 more), Panama, Colombia, Aruba
INSIDE
$5,553
OCEANVIEW
$6,543
BALCONY
$7,929
SUITE
$17,334
From 5,553
View Trip
24 Day Panama Canal & Pacific Coast with Princess
Cruise

24 Days (23 Nights) Vancouver to Fort Lauderdale
Cruise Line: Princess
Ship: Caribbean Princess
Departure: 23 September 2025
Countries Visited: Canada, USA, Mexico, Nicaragua (+3 more), Costa Rica, Panama, Aruba
INSIDE
$3,995
OCEANVIEW
$4,399
BALCONY
$5,975
SUITE
$8,133
From 3,995
View Trip
22 Day Panama Canal Repositioning Cruise with Norwegian Cruise Line
Cruise

22 Days (21 Nights) Seattle to Miami
Ship: Norwegian Joy
Departure: 29 September 2025
Countries Visited: USA, Canada, Mexico, Guatemala (+3 more), Costa Rica, Panama, Colombia
Free At Sea OfferExclusive Solo Offer
INSIDE
$5,687
OCEANVIEW
$6,750
BALCONY
$7,357
SUITE
$8,344
From 5,687
View Trip
44 Day Best of Central America with Intrepid Travel
Tour
 (1)

44 Days Playa del Carmen to Panama City
Operated By: Intrepid Travel
Departures: May 2024 to Nov 2025
Trip Styles: Adventure, Small Group
Countries Visited: Mexico, Belize, Guatemala, Honduras (+4 more), El Salvador, Nicaragua, Costa Rica, Panama
Limited Time Sale
Save 758
From 6,192
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62 Day Longitudinal World Cruise IV with Viking Cruises
Cruise

62 Days (61 Nights) Milwaukee to Buenos Aires
Cruise Line: Viking Cruises
Ship: Viking Polaris
Departure: 15 September 2025
Countries Visited: USA, Canada, Mexico, Panama (+5 more), Ecuador, Peru, Chile, Antarctica, Argentina
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$85,255
SUITE
$112,695
Save 1,740
From 85,255
View Trip
34 Day Seattle To Miami with Cunard
Cruise
 (8)

34 Days (33 Nights) Seattle to Miami
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 25 September 2025
Countries Visited: USA, Mexico, Costa Rica, Panama (+8 more), Colombia, Aruba, Puerto Rico, Antigua and Barbuda, Saint Lucia, Barbados, Sint Maarten, Virgin Islands
INSIDE
$6,149
OCEANVIEW
$7,238
BALCONY
$8,574
SUITE
$18,623
From 6,149
View Trip
31 Day San Francisco To Miami with Cunard
Cruise
 (8)

31 Days (30 Nights) San Francisco to Miami
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 28 September 2025
Countries Visited: USA, Mexico, Costa Rica, Panama (+8 more), Colombia, Aruba, Puerto Rico, Antigua and Barbuda, Saint Lucia, Barbados, Sint Maarten, Virgin Islands
INSIDE
$5,554
OCEANVIEW
$6,445
BALCONY
$7,583
SUITE
$16,840
From 5,554
View Trip
87 Day From the Arctic to Antarctica with Viking Cruises
Cruise

87 Days (86 Nights) Nuuk to Buenos Aires
Cruise Line: Viking Cruises
Ship: Viking Octantis
Departure: 03 September 2025
Countries Visited: Greenland, Canada, USA, Mexico (+8 more), Panama, Ecuador, Peru, Chile, Argentina, Antarctica, South Georgia Island, Falkland Islands
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$157,900
Save 3,595
From 157,900
View Trip
41 Day Seattle To Miami with Cunard
Cruise
 (8)

41 Days (40 Nights) Seattle to Miami
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 18 September 2025
Countries Visited: USA, Canada, Mexico, Costa Rica (+9 more), Panama, Colombia, Aruba, Puerto Rico, Antigua and Barbuda, Saint Lucia, Barbados, Sint Maarten, Virgin Islands
INSIDE
$7,537
OCEANVIEW
$8,923
BALCONY
$10,656
SUITE
$24,763
From 7,537
View Trip
Results: 15 results

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