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Cruises from Spain to Italy

Are you looking for a cruise from Spain to Italy? August is the most popular month to cruise between Spain and Italy and there are 220 departures available from sixteen of the world's leading cruise lines.
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115 Cruises (220 Cruise Departures)
8 Day Mediterranean with France & Italy with Princess
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departures: May 2024 to Aug 2025
Countries Visited: Spain, Gibraltar, France, Italy
INSIDE
$1,667
OCEANVIEW
$1,815
BALCONY
$1,982
SUITE
$2,667
From 1,667
View Trip
10 Day France Intensive Voyage with Azamara Cruises
Cruise
 (1)

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 02 April 2025
Countries Visited: Spain, France, Corsica, Italy
INSIDE
$3,216
OCEANVIEW
$3,678
BALCONY
$4,368
SUITE
$6,091
From 3,216
View Trip
24 Day Mediterranean Tapestry & Empires with Holland America
Cruise
 (1)

24 Days (23 Nights) Barcelona to Venice
Cruise Line: Holland America
Ship: Oosterdam
Departure: 12 June 2024
Countries Visited: Spain, France, Italy, Sicily (+6 more), Malta, Tunisia, Greece, Turkey, Albania, Croatia
Have It All Offer
INSIDE
$7,573
OCEANVIEW
$7,781
BALCONY
$9,533
SUITE
-
From 7,573
View Trip
12 Day Around Italy's Boot: Venice Overnight with Holland America
Cruise
 (1)

12 Days (11 Nights) Barcelona to Venice
Cruise Line: Holland America
Ship: Oosterdam
Departure: 10 September 2025
Countries Visited: Spain, France, Italy, Greece (+2 more), Croatia, Montenegro
Have It All Offer
INSIDE
$3,941
OCEANVIEW
$4,139
BALCONY
$5,278
SUITE
$7,159
From 3,941
View Trip
8 Day Mediterranean with France & Italy with Princess
Cruise
 (3)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Majestic Princess
Departure: 04 March 2025
Countries Visited: Spain, Gibraltar, Corsica, Italy
INSIDE
$1,375
OCEANVIEW
-
BALCONY
$1,631
SUITE
$2,147
From 1,375
View Trip
13 Day Best Of The Mediterranean Voyage with Azamara Cruises
Cruise
 (1)

13 Days (12 Nights) Barcelona to Venice
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 06 September 2025
Countries Visited: Spain, France, Monaco, Italy (+3 more), Montenegro, Croatia, Slovenia
INSIDE
$6,090
OCEANVIEW
$6,552
BALCONY
$7,241
SUITE
$9,540
From 6,090
View Trip
11 Day Marvelous Mediterranean with Oceania Cruises
Cruise
 (2)

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 15 May 2024
Countries Visited: Spain, France, Monaco, Italy (+1 more), Corsica
Exclusive Deal
INSIDE
-
OCEANVIEW
$9,774
BALCONY
-
SUITE
-
Save 2,086
From 9,774
View Trip
23 Day Scenic Strands & Havens with Oceania Cruises
Cruise
 (1)

23 Days (22 Nights) Malaga to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 07 October 2025
Countries Visited: Spain, Morocco, Portugal, Tunisia (+4 more), Malta, Greece, Sicily, Italy
Exclusive Deal
INSIDE
$9,807
OCEANVIEW
$10,569
BALCONY
$15,608
SUITE
$21,152
Save 2,073
From 9,807
View Trip
8 Day Southern France and the Italian Riviera by Sea - with Smithsonian Journeys with Ponant
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Ponant
Ship: Le Laperouse
Departure: 02 October 2025
Countries Visited: Spain, France, Italy
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$8,301
SUITE
$13,907
Save 159
From 8,301
View Trip
8 Day Mediterranean Spring with Oceania Cruises
Cruise
 (2)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 06 May 2025
Countries Visited: Spain, France, Monaco, Italy
Exclusive Deal
INSIDE
$4,129
OCEANVIEW
$4,357
BALCONY
$6,109
SUITE
$8,010
Save 2,031
From 4,129
View Trip
11 Day Radiant Spain & Italy with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Riviera
Departure: 03 August 2024
Countries Visited: Spain, France, Monaco, Italy
Exclusive DealSingles Special Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$8,359
SUITE
-
Save 2,071
From 8,359
View Trip
21 Day Western Mediterranean & Adriatic Explorer with Princess
Cruise
 (2)

21 Days (20 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Island Princess
Departure: 05 August 2024
Countries Visited: Spain, Gibraltar, France, Italy (+5 more), Sicily, Malta, Greece, Montenegro, Croatia
INSIDE
$5,129
OCEANVIEW
$5,340
BALCONY
$6,975
SUITE
$7,643
From 5,129
View Trip
11 Day French, Spanish & Italian Rivieras with Princess
Cruise
 (2)

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Island Princess
Departure: 05 August 2024
Countries Visited: Spain, Gibraltar, France, Italy
INSIDE
-
OCEANVIEW
$2,919
BALCONY
$3,907
SUITE
$4,065
From 2,919
View Trip
23 Day Jet Set Journey with Oceania Cruises
Cruise
 (1)

23 Days (22 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Riviera
Departure: 03 August 2024
Countries Visited: Spain, France, Monaco, Italy (+3 more), Sicily, Malta, Greece
Exclusive Deal
INSIDE
$11,836
OCEANVIEW
$13,668
BALCONY
$15,806
SUITE
-
Save 2,094
From 11,836
View Trip
21 Day France & Spanish Treasures with Seabourn
Cruise

21 Days (20 Nights) Barcelona to Rome
Cruise Line: Seabourn
Ship: Ovation
Departure: 10 October 2024
Countries Visited: Spain, France, Tunisia, Italy (+2 more), Sicily, Malta
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$19,126
SUITE
-
From 19,126
View Trip
12 Day Canary Islands And Madeira with MSC Cruises
Cruise

12 Days (11 Nights) Santa Cruz de Tenerife to Venice
Cruise Line: MSC Cruises
Ship: MSC Opera
Departure: 23 March 2025
Countries Visited: Spain, Morocco, Sicily, Greece (+2 more), Italy, Croatia
Save And Sail Offer
INSIDE
$1,567
OCEANVIEW
$1,914
BALCONY
$2,844
SUITE
$4,280
From 1,567
View Trip
11 Day Flavors Of The Mediterranean with Regent Seven Seas
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Navigator
Departure: 18 September 2024
Countries Visited: Spain, France, Italy
Mutiple Deals Available
INSIDE
-
OCEANVIEW
$7,564
BALCONY
-
SUITE
$12,193
Save 8,486
From 7,564
View Trip
8 Day A Journey Of Riviera Reveries And Italian Icons with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 26 August 2024
Countries Visited: Spain, France, Corsica, Sardinia (+1 more), Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$7,994
SUITE
$9,261
From 13,964
View Trip
12 Day Barcelona to Civitavecchia with Virgin Voyages
Cruise

12 Days (11 Nights) Barcelona to Rome
Cruise Line: Virgin Voyages
Ship: Scarlet Lady
Departure: 03 November 2024
Countries Visited: Spain, France, Italy, Corsica (+1 more), Sardinia
INSIDE
$2,613
OCEANVIEW
$2,613
BALCONY
$2,863
SUITE
$6,785
From 2,613
View Trip
11 Day Barcelona to Rome with Silversea
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Silversea
Ship: Silver Moon
Departure: 16 August 2024
Countries Visited: France, Italy, Spain
Essential FareDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$8,959
BALCONY
$11,236
SUITE
-
From 8,959
View Trip
15 Day Italy And Adriatic with Cunard
Cruise

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 18 August 2025
Countries Visited: Spain, Malta, Italy, Croatia (+2 more), Montenegro, Greece
INSIDE
$2,766
OCEANVIEW
$3,212
BALCONY
$3,657
SUITE
$7,667
From 2,766
View Trip
22 Day Adriatic And Western Mediterranean with Cunard
Cruise

22 Days (21 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Victoria
Departures: May 2026 to Jun 2026
Countries Visited: Spain, France, Italy, Corsica (+4 more), Sicily, Greece, Montenegro, Croatia
INSIDE
$3,867
OCEANVIEW
$4,263
BALCONY
$4,857
SUITE
$10,203
From 3,867
View Trip
8 Day A Journey From Barcelona To Civitavecchia with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 16 June 2025
Countries Visited: Spain, France, Corsica, Italy (+1 more), Sardinia
Exclusive DealThe Total Luxury Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$5,504
SUITE
$6,692
From 8,237
View Trip
18 Day Canary Islands And Madeira with MSC Cruises
Cruise

18 Days (17 Nights) Las Palmas de Gran Canaria to Venice
Cruise Line: MSC Cruises
Ship: MSC Opera
Departure: 17 March 2025
Countries Visited: Spain, Portugal, Morocco, Sicily (+3 more), Greece, Italy, Croatia
Save And Sail Offer
INSIDE
$3,191
OCEANVIEW
$4,032
BALCONY
$6,280
SUITE
$9,715
From 3,191
View Trip
13 Day Best Of The Mediterranean Voyage with Azamara Cruises
Cruise

13 Days (12 Nights) Barcelona to Venice
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 21 April 2025
Countries Visited: Spain, France, Italy, Montenegro (+2 more), Croatia, Slovenia
INSIDE
$5,078
OCEANVIEW
$5,539
BALCONY
$6,229
SUITE
$7,953
From 5,078
View Trip
15 Day Italy, France And Spain with Cunard
Cruise

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 07 September 2026
Countries Visited: Spain, Corsica, Sicily, Italy (+1 more), France
INSIDE
$2,974
OCEANVIEW
$3,320
BALCONY
$3,766
SUITE
$7,924
From 2,974
View Trip
10 Day Canary Islands And Madeira with MSC Cruises
Cruise

10 Days (9 Nights) Santa Cruz de Tenerife to Bari
Cruise Line: MSC Cruises
Ship: MSC Opera
Departure: 23 March 2025
Countries Visited: Spain, Morocco, Sicily, Greece (+1 more), Italy
Save And Sail Offer
INSIDE
$1,748
OCEANVIEW
$2,194
BALCONY
$3,382
SUITE
$5,213
From 1,748
View Trip
8 Day Italy And Spain with Cunard
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 17 August 2026
Countries Visited: Spain, Sardinia, Sicily, Italy
INSIDE
$1,684
OCEANVIEW
$1,882
BALCONY
$2,080
SUITE
$4,654
From 1,684
View Trip
8 Day Italy, France And Spain with Cunard
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 07 September 2026
Countries Visited: Spain, Corsica, Sicily, Italy
INSIDE
$1,635
OCEANVIEW
$1,783
BALCONY
$1,932
SUITE
$4,258
From 1,635
View Trip
11 Day Greek Isles & Turkey Cruise with Celebrity Cruises
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departures: May 2025 to Oct 2025
Countries Visited: Spain, Greece, Turkey, Italy
Exclusive Offer
INSIDE
$2,363
OCEANVIEW
$3,096
BALCONY
$3,096
SUITE
$8,565
Save 3,787
From 2,363
View Trip
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