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Cruises from Rome to Barcelona

Are you looking for a cruise from Rome to Barcelona? September is the most popular month to cruise between Rome and Barcelona and there are 148 departures available from fifteen of the world's leading cruise lines.
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88 Cruises (148 Cruise Departures)
11 Day Grand Mediterranean with Princess
Cruise
 (3)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Majestic Princess
Departure: 30 June 2025
Countries Visited: Italy, Greece, Turkey, Sicily (+1 more), Spain
INSIDE
$2,775
OCEANVIEW
-
BALCONY
$4,022
SUITE
$4,924
From 2,775
View Trip
8 Day Iconic Western Mediterranean with Viking Cruises
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+8 more), Viking Neptune, Viking Saturn, Viking Sea, Viking Sky, Viking Star, Viking Vela, Viking Venus, Viking Vesta
Departures: Jul 2024 to Sep 2026
Countries Visited: Italy, Monaco, France, Spain
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$4,450
SUITE
$6,925
Save 1,171
From 4,450
View Trip
11 Day Renaissance Triumphs with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Riviera
Departure: 04 November 2024
Countries Visited: Italy, Sicily, Malta, France (+1 more), Spain
Exclusive DealSingles Special Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$6,398
SUITE
$9,091
Save 2,052
From 6,398
View Trip
11 Day Mediterranean Melange with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 29 October 2025
Countries Visited: Italy, Sicily, Sardinia, Corsica (+3 more), Monaco, France, Spain
Exclusive Deal
INSIDE
$4,419
OCEANVIEW
$4,874
BALCONY
$7,320
SUITE
$9,854
Save 2,031
From 4,419
View Trip
10 Day Islands Of The Med Voyage with Azamara Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 18 October 2024
Countries Visited: Italy, Corsica, Sardinia, Spain
INSIDE
-
OCEANVIEW
$2,869
BALCONY
-
SUITE
-
From 2,869
View Trip
11 Day Autumnal Mediterranean with Oceania Cruises
Cruise
 (2)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 18 October 2025
Countries Visited: Italy, Sicily, Malta, Tunisia (+3 more), Monaco, France, Spain
Exclusive Deal
INSIDE
$4,726
OCEANVIEW
$5,181
BALCONY
$7,626
SUITE
$10,309
Save 2,034
From 4,726
View Trip
19 Day Malta & Mediterranean Romance with Holland America
Cruise
 (1)

19 Days (18 Nights) Rome to Barcelona
Cruise Line: Holland America
Ship: Oosterdam
Departure: 01 September 2024
Countries Visited: Italy, Sicily, Malta, Greece (+5 more), Turkey, Albania, Corsica, France, Spain
Have It All Offer
INSIDE
$5,178
OCEANVIEW
$5,822
BALCONY
$6,802
SUITE
$9,594
From 5,178
View Trip
10 Day Cities Of The Western Med Voyage with Azamara Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 31 October 2024
Countries Visited: Italy, Monaco, France, Spain
INSIDE
$2,033
OCEANVIEW
$2,260
BALCONY
$4,219
SUITE
$5,512
From 2,033
View Trip
12 Day Rivieras & Yacht Havens Voyage with Azamara Cruises
Cruise
 (1)

12 Days (11 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 26 August 2025
Countries Visited: Italy, Monaco, France, Spain
INSIDE
$4,368
OCEANVIEW
$4,829
BALCONY
$5,519
SUITE
$7,588
From 4,368
View Trip
8 Day Iconic Italy & A Taste Of Spain with Regent Seven Seas
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 01 May 2024
Countries Visited: Italy, Sicily, Malta, Spain
Early Booking Saving
INSIDE
-
OCEANVIEW
-
BALCONY
$11,392
SUITE
$12,867
Save 2,108
From 11,392
View Trip
8 Day Italy, France And Spain with Cunard
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 09 June 2025
Countries Visited: Italy, Corsica, Spain
INSIDE
$1,338
OCEANVIEW
$1,556
BALCONY
$1,783
SUITE
$3,744
From 1,338
View Trip
15 Day Italy And Adriatic with Cunard
Cruise

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departures: Jun 2025 to Sep 2025
Countries Visited: Italy, Greece, Montenegro, Croatia (+2 more), Malta, Spain
INSIDE
$2,677
OCEANVIEW
$3,033
BALCONY
$3,390
SUITE
$7,399
From 2,677
View Trip
8 Day A Journey From Civitavecchia To Barcelona with Explora Journeys
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departures: Jun 2025 to Jul 2025
Countries Visited: Italy, Sicily, Sardinia, Spain
Exclusive DealThe Total Luxury Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$6,192
SUITE
$7,529
From 9,266
View Trip
11 Day Greek Isles & Turkey with Celebrity Cruises
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departures: Jul 2024 to Oct 2024
Countries Visited: Italy, Greece, Turkey, Malta (+1 more), Spain
Exclusive Offer
INSIDE
$2,575
OCEANVIEW
$2,617
BALCONY
$3,201
SUITE
$11,418
Save 3,451
From 2,575
View Trip
10 Day Italy, France & Spain Cruise with Celebrity Cruises
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 24 August 2024
Countries Visited: Italy, Sicily, Malta, Corsica (+2 more), France, Spain
Exclusive Offer
INSIDE
$2,277
OCEANVIEW
$2,586
BALCONY
$2,990
SUITE
$7,933
Save 2,878
From 2,277
View Trip
15 Day Mediterranean with Greek Isles, Italy & Turkey with Princess
Cruise

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departures: Jun 2024 to Jul 2024
Countries Visited: Italy, Greece, Turkey, Montenegro (+2 more), Sicily, Spain
INSIDE
$5,447
OCEANVIEW
$5,902
BALCONY
$7,358
SUITE
$8,768
From 5,447
View Trip
16 Day Civitavecchia to Barcelona with Silversea
Cruise

16 Days (15 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Ray
Departure: 30 May 2025
Countries Visited: Italy, Sicily, France, Spain
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$17,919
From 17,919
View Trip
8 Day Spanish & Italian Hot Spots with Virgin Voyages
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Virgin Voyages
Ship: Scarlet Lady
Departure: 06 July 2025
Countries Visited: Italy, Sicily, Corsica, Spain
Up to 80% Off Second Sailor + Free Upgrade
INSIDE
$2,328
OCEANVIEW
$2,737
BALCONY
$3,031
SUITE
$6,873
From 2,328
View Trip
10 Day Italian Riviera & France with Celebrity Cruises
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departure: 04 June 2024
Countries Visited: Italy, France, Spain
Exclusive Offer
INSIDE
$2,309
OCEANVIEW
$5,571
BALCONY
$2,918
SUITE
$7,174
Save 2,862
From 2,309
View Trip
15 Day Mediterranean with Greek Isles, Italy & Turkey with Princess
Cruise

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departure: 06 September 2025
Countries Visited: Italy, Greece, Turkey, Montenegro (+2 more), Sicily, Spain
INSIDE
$3,730
OCEANVIEW
$4,595
BALCONY
$5,901
SUITE
$7,357
From 3,730
View Trip
15 Day Italy, France And Spain with Cunard
Cruise

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 04 August 2025
Countries Visited: Italy, France, Sardinia, Sicily (+2 more), Corsica, Spain
INSIDE
$2,677
OCEANVIEW
$3,033
BALCONY
$3,568
SUITE
$7,399
From 2,677
View Trip
15 Day Mediterranean with Greek Isles, Italy & Turkey with Princess
Cruise

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departure: 10 August 2024
Countries Visited: Italy, Greece, Turkey, Montenegro (+2 more), Sicily, Spain
INSIDE
$6,313
OCEANVIEW
$7,090
BALCONY
$9,436
SUITE
$11,230
From 6,313
View Trip
22 Day Greece, Adriatic And Western Mediterranean with Cunard
Cruise

22 Days (21 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 26 May 2025
Countries Visited: Italy, Greece, Montenegro, Croatia (+3 more), Malta, Corsica, Spain
INSIDE
$4,283
OCEANVIEW
$4,521
BALCONY
$5,174
SUITE
$11,005
From 4,283
View Trip
9 Day Civitavecchia to Barcelona with Silversea
Cruise

9 Days (8 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Ray
Departure: 23 September 2025
Countries Visited: Italy, Spain
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$12,078
From 12,078
View Trip
8 Day Italy, France And Spain with Cunard
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 11 August 2025
Countries Visited: Italy, France, Corsica, Spain
INSIDE
$1,427
OCEANVIEW
$1,645
BALCONY
$1,873
SUITE
$3,833
From 1,427
View Trip
8 Day A Journey From Rome To Tarragona with Explora Journeys
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 16 September 2024
Countries Visited: Spain, Malta, Sicily, Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$7,618
SUITE
$9,261
From 9,499
View Trip
8 Day A Journey From Civitavecchia To Barcelona with Explora Journeys
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departures: Jun 2025 to Sep 2025
Countries Visited: Italy, Sicily, Tunisia, Sardinia (+1 more), Spain
Exclusive DealThe Total Luxury Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$5,197
SUITE
$6,341
From 7,796
View Trip
15 Day Italy, Spain And Adriatic with Cunard
Cruise

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 24 August 2026
Countries Visited: Italy, Greece, Montenegro, Croatia (+2 more), Malta, Spain
INSIDE
$3,320
OCEANVIEW
$3,667
BALCONY
$4,162
SUITE
$8,914
From 3,320
View Trip
8 Day Mediterranean Tapestry with Regent Seven Seas
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Navigator
Departure: 15 November 2024
Countries Visited: Italy, France, Spain
Mutiple Deals Available
INSIDE
-
OCEANVIEW
$3,830
BALCONY
$3,993
SUITE
$4,953
Save 7,440
From 3,830
View Trip
15 Day Mediterranean with Greek Isles, Italy & Turkey with Princess
Cruise

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departures: Apr 2025 to Aug 2025
Countries Visited: Italy, Greece, Turkey, Montenegro (+2 more), Sicily, Spain
INSIDE
$3,648
OCEANVIEW
$4,628
BALCONY
$5,202
SUITE
$6,282
From 3,648
View Trip
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